Promethazine Promethazine is really a phenothiazine spinoff, which differs structurally in the antipsychotic phenothiazines because of the existence of the branched facet chain and no ring substitution.
e., several copies of your gene for cytochrome P450 isoenzyme 2D6 or significant morphine concentrations). Kids with sleep apnea can be specially delicate to the respiratory depressant outcomes of codeine.
This product may consist of inactive components, which often can cause allergic reactions or other issues. Speak with your pharmacist For additional information.
Consume loads of fluids while you're employing this medication Until or else directed by your health care provider. The fluid will help loosen the mucus in your lungs.
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The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals a lot less than 6 yrs of age.
The subsequent severe adverse reactions are described, or explained in increased element, in other sections:
The phosphate salt of codeine takes place as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and a bit soluble in Liquor.
Phenothiazines are connected to dystonic reactions, significantly in pediatric sufferers who've an acute sickness affiliated with dehydration. Paradoxical reactions, which include dystonia, torticollis, tongue protrusion, hyperexcitability, and abnormal movements have been noted in people subsequent only one administration of promethazine. Discontinue Promethazine HCl and Codeine Phosphate Oral Solution if a paradoxical response takes place.
Postmarketing situations of respiratory melancholy, like fatalities happen to be claimed with use of promethazine in pediatric individuals.
Meticulously evaluate the dose using a special measuring Promethazine codeine syrup unit/spoon. Don't utilize a residence spoon since you might not get the right dose.
Children should be supervised throughout bicycle riding and other possibly harmful activities to stay away from damage. Limit alcoholic beverages. Speak with your physician Should you be using cannabis (cannabis).
one)]. All sufferers handled with opioids demand very careful monitoring for signs of abuse and habit, given that use of opioid analgesic and antitussive goods carries the risk of addiction even under ideal professional medical use.
Codeine and promethazine, two in the Energetic components in Promethazine HCl and Codeine Phosphate Oral Alternative, could create marked drowsiness and impair the mental and/or Actual physical abilities essential for the performance of probably dangerous duties which include driving a car or working machinery. Recommend sufferers to prevent participating in hazardous duties requiring psychological alertness and motor coordination just after ingestion of Promethazine HCl and Codeine Phosphate Oral Option.